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Abnormal thyroid function-hypo- and hyperthyroidism-can manifest as myopathy with symptoms of train-induced muscle fatigue, cramping, muscle pain and should include proximal weakness or muscle hypertrophy (particularly of the calves). Hypothyroidism up-regulates glycogen synthesis and down-regulates glycogenolysis and glycolysis; conversely, hyperthyroidism does the reverse, up-regulating glycogenolysis and glycolysis whereas down-regulating glycogen synthesis. Prolonged hypo- and hyperthyroid myopathy results in atrophy of sort II (fast-twitch/glycolytic) muscle fibres, and a predominance of kind I (gradual-twitch/oxidative) muscle fibres. Muscle biopsy shows abnormal muscle glycogen: excessive accumulation in hypothyroidism and low accumulation in hyperthyroidism. Hypothyroid myopathy consists of Kocher-Debre-Semelaigne syndrome (childhood-onset), Hoffman syndrome (adult-onset), myasthenic syndrome, and atrophic type. In patients with elevated progress hormone, muscle biopsy includes, amongst different options, excess glycogen deposition. EPG5-related Vici syndrome is a multisystem disorder, Healthy Flow Blood supplement a congenital disorder of autophagy, with muscle biopsy displaying excess glycogen accumulation, amongst other myopathic options. McArdle disease also have hypertrophy of the calf muscles.

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